YES!!! I grew up in sarasota bradenton. there are many areas that are not so nice to hang around, especially at night. the street known as "Old 301" which is a main rode that paralells US41 is where a lot of hookers hang out and a lot of drugs activity goes on.
In the area between Sarasota and Bradenton, most of the streets off of US41 (tamiami trail) near the airport are fairly bad too. Some of the other answers to this question are right- Bradenton does not have a real "ghetto" compared to larger US cities. So the crime rate is not really as high.
However, the areas I listed, along with the entire roads and off streets in north sarasota of "Dr. Martin Luther King Drive", Old Bradenton Road, and Orange Ave" see a ton of drug activity and there tend to be swarms of people loitering along the streets as you drive through so it can be intimidating.